Overcoming cellular regulation is essential for developing breakthrough biologics, gene therapies, and vaccines.
ExcepGen's scientific platform is focused on developing next generation technology to address cellular regulation explicitly and systematically in the drug discovery and drug development process. Our regulation-centric platform allows us to envision conceptually new treatment types. By programming cells to be less vulnerable to external stimuli, we can target complex proteins and their associated signaling pathways with novel, enduring, and holistic therapeutic approaches.
Until now, this has been impossible. At ExcepGen, we've demonstrated that inhibiting the cell's ability to negatively respond to external stimuli has enormous potential to improve the drug discovery and development process.
We streamline complex cellular communication making the input-to-output function reliable.
We can access previously impossible drug targets which allows us to discover novel therapeutics.
We boldly strive for disease elimination by confronting "first principles" in biology.
Our COVID-19 program leverages core ExcepGen technology to express multiple antigens of the SARS-CoV-2 virus, enabling virus-like particle self-assembly.
We plan to expand into additional infectious diseases, cancer, and other therapeutic vaccines.
We are developing a vectored, gene-encoded therapeutic antibody with the aim of enabling the body to produce its own durable, stable expression of a therapeutic in vivo (vs. traditional manufactured antibody drugs).
We plan to expand into broader applications including auto-immune diseases and enzyme replacement therapies.
We're using ExcepGen technology to create antibodies that target previously inaccessible GPCRs and ion channels.
We plan to expand into additional targets over time.
Biological systems operate within a certain range of limits. In that range, they must be responsive enough to receive information from the external environment while, at the same time, able to resist large changes induced by external stimuli. This makes cells adaptable and functionally reliable. Indeed, to ensure their adaptability and functionality, cells use multiple, often redundant molecular regulatory mechanisms. These include activation or deactivation of signaling pathways, gene expression changes, protein alterations, and more.
Regulatory mechanisms form networks whose complexity and interconnectedness can significantly hinder drug discovery and development. Often, drug candidates are only targeted under one specific network state, even though cellular networks can adapt and change. Until now, it has been difficult to create drugs that alter cells in multiple contexts and reliably treat disease.
At ExcepGen, we’re using our knowledge of cellular regulation to create more effective drugs. For instance we can:
Often, researchers want to create drugs that target complex proteins. However, these complex proteins may natively adopt particular structures that are hard to reproduce outside of their natural cellular/organismal context. With our knowledge of the regulatory mechanisms that impact protein production, we can produce proteins that look and function like their natural counterparts. By using these proteins as natural targets, we can develop more effective drugs and therapeutics.
While gene therapies are highly promising, they often fail because the genes they introduce cease to express over time. At ExcepGen, we understand and can overcome the regulatory mechanisms that lead to this decreased expression. Thus, we can create gene therapies with sustained gene expression and better clinical results.